Long-term expression of zinc transporters in hippocampus following penicillin-induced developmental seizures and its regulation by E-64d
نویسندگان
چکیده
منابع مشابه
Long-term expression of zinc transporters in hippocampus following penicillin-induced developmental seizures and its regulation by E-64d
Autophagy has been shown to be involved in the pathophysiology of developmental seizure-induced brain damage. The present study aimed to examine whether E-64d, an autophagy inhibitor, was able to facilitate developmental seizure-induced hippocampal mossy fiber sprouting, in particular sprouting-associated zinc transporter signals. Recurrent seizures were induced by penicillin every other day in...
متن کاملLong-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.
Despite the effective use of antiepileptic drugs (AEDs) for epilepsy, therapeutic failure occurs in 30% of patients. Novel approaches are targeting the inhibition of epileptogenesis. N-acetyl-5-methoxytryptamine (melatonin) is an indoleamine produced mainly by the pineal gland, and has been observed to exhibit antiepileptic and neuroprotective effects in experimental and clinical investigations...
متن کاملthe effects of keyword and context methods on pronunciation and receptive/ productive vocabulary of low-intermediate iranian efl learners: short-term and long-term memory in focus
از گذشته تا کنون، تحقیقات بسیاری صورت گرفته است که همگی به گونه ای بر مثمر ثمر بودن استفاده از استراتژی های یادگیری لغت در یک زبان بیگانه اذعان داشته اند. این تحقیق به بررسی تاثیر دو روش مختلف آموزش واژگان انگلیسی (کلیدی و بافتی) بر تلفظ و دانش لغوی فراگیران ایرانی زیر متوسط زبان انگلیسی و بر ماندگاری آن در حافظه می پردازد. به این منظور، تعداد شصت نفر از زبان آموزان ایرانی هشت تا چهارده ساله با...
15 صفحه اولDoxepin improves stress-impaired long-term potentiation and gene expression of BDNF in the rat hippocampus
Introduction: Stress is associated with neurological and cognitive disorders. It has been suggested that doxepin, in addition to its influence on the content of neurotransmitters, has probable neuroprotective effects as well. Therefore, the aim of this study was to investigate the effects of doxepin on synaptic plasticity and brain-derived neurotrophic factor (BDNF) gene expression in the rat h...
متن کاملNeuronal damage of the dorsal hippocampus induced by long-term right common carotid artery occlusion in rats
Objective(s):The present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (UCO) on the dorsal hippocampal neurons in rats. Materials and Methods:Sixty four male Sprague-Dawley rats aged 4 months were divided into two groups of sham and UCO. These two groups were further divided into 4 sets of histopath...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2016
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2016.3276